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Targeting glutathione metabolism: partner in crime in anticancer therapy

NNMT (nicotinamide N-methyltransferase) is a cytosolic enzyme that catalyzes a specific methylation reaction: it transfers a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing two products 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH)

Conen, D, Ke Wang, M, Popova, E, Chan, MT, Landoni, G, Cata, JP, Reimer, C, McLean, SR, Srinathan, S, Reyes, JT, Grande, AM, Tallada, AG, Sessler, DI, Fleischmann, E, Kabon, B, Voltolini, L, Cruz, P, Maziak, D, Gutirrez-Soriano, L, McIntyre, WF, Tandon, V, Martnez-Tllez, E, Guerra-Londono, JJ, DuMerton, D, Wong, RH, McGuire, AL, Kidane, B, Roux, DP, Shargall, Y, Wells, JR, Ofori, SN, Vincent, J, Xu, L, Li, Z, Eikelboom, JW, Jolly, SS, Healey, JS, Devereaux, PJ, Wang, MK, Wells, JR, Healey, JS, McIntyre, WF, Sessler, DI, Rajaram, R, Vaporciyan, AA, Mehran, RJ, Sepesi, B, Walsh, GL, Rice, DC, Swisher, SG

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MASH (metabolic dysfunction-associated steatohepatitis) is a progressive liver disease characterized by fat accumulation, inflammation, and fibrosis