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LD50 is a crucial number for determining the safety of any drug, and it is typically determined through animal testing, with known LD50 values for common substances like caffeine and aspirin 4m6s

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An important theoretical concern exists: c-Met is overexpressed in multiple human cancers (gastric, lung, colorectal), and chronic c-Met pathway stimulation could potentially influence cancer riskthough this has not been studied longitudinally even in animals