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Finally, 7 pathways grouped within the biosynthesis class were also significantly less abundant with an increase in NR, which were (I) the diacylglycerol biosynthesis III pathway, (II) and (III) the NAD salvage pathways I and V (PNC IV and V cycles), (IV) and (V) the phosphatidylglycerol biosynthesis I and II (plastidic non plastidic) pathways, (VI) the isoprene biosynthesis I pathway and (VII) the methylerythritol phosphate pathway II

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In addition, this enzyme was also found in the nucleolus of various cell types, such as human HeLa cells, mouse L929 cells (fibroblast cell line), but also in mouse testes, specifically in spermatogonia, spermatocytes and spermatids