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The risk of renal adverse reactions was increased in patients with a history of renal impairment (the weight management trials included 65 patients with a history of moderate or severe renal impairment at baseline), and occurred more frequently during dose titration
Additionally, one clinical study reported that consumption of chlorogenic acid-enriched coffee not only improved plasma antioxidant capacity and decreased plasma lipid and protein oxidation but also donated to enhancing cardiovascular health in people with hypercholesterolemia [169]
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Higher concentration: mixing to 5 mg/mL keeps injection volumes small even at the top of the range useful when titrating toward 4.5 mg, the dose linked with the largest weight reductions in early trials [4]
