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For individuals with conditions like pernicious anaemia, an autoimmune disorder that attacks the protein needed to absorb B12, oral supplements are often completely ineffective

The peptide community treats nasal administration as either completely legitimate or totally ineffective depending who you ask

TB-500 the fragment has less compound-specific work, though the parent molecule Thymosin Beta-4 has a substantial older literature stretching back to the 1980s

Early, small, short-term studies on premenopausal women diagnosed with HSDD have shown some evidence of increased libido, but theres no evidence yet that it has this effect on menopausal women

Occasionally another drug might be indicated (see section on adjuvant drugs, below)