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The second stage is Trem2-dependent and is marked by increased expression of genes involves in lipid metabolism and phagocytic pathway genes (e.g., Lpl, Cst , and Cd9 ), causing excessive inflammatory responses and neurodegeneration (Keren-Shaul et al., 2017

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P67phox/nox2 inhibits psoriasis by regulating the HIF-1-glycolysis axis via p53-AMPK in keratinocytes

PMCID: PMC5228623