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The most active Mannich base, inhibitors of plasmodial and kinetoplastid flavoenzymes [33,34], was 3-DAP, with low micromolar IC 50 values against TGR

As the condition worsens, common symptoms include: weakness and fatigue light-headedness and dizziness palpitations and rapid heartbeat shortness of breath a sore tongue that has a red, beefy appearance nausea or poor appetite weight loss diarrhea yellowish tinge to the skin and eyes

The gradual dose titration schedule recommended in the prescribing information is specifically designed to minimize these effects

Conversely, CSD might be linked to dysfunction in the mitochondria