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Chemical modifications of nucleic acid drugs and their delivery systems for gene-based therapy

As an alternative, pyruvate kinase (PK) and phosphoenolpyruvate carboxykinase (PEPCK) work together to convert oxaloacetate (OAA) to pyruvate

Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update

Each year, acetaminophen-associated overdoses account for tens of thousands of emergency room visits and thousands of hospitalizations in the United States

13a, Supplementary Table 9), suggesting that the distinct rotamer orientation of H296 ECL2 in Cagri-bound CTR (to accommodate the Glu linker) and/or the observed more open ECL3 conformation induced by the lipidated peptide may facilitate or stabilize an active CTR conformation (Supplementary Fig