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Similar to certain synaptic terminals of the mammalian brain, presynaptic plasticity processes are of pivotal importance for Drosophila olfactory learning and memory

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Although AD and VaD share common vascular risk factors, the contribution of small artery disease to VaD pathogenesis may be greater than that of AD [120].In fact, studies have found that neuropathic changes can be evident 20 years before the onset of dementia and that there is a substantial neuronal loss in the MCI stage, which is considered a transitional state before the onset of dementia [121]