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Comprehensive analysis supports the fundamental difference between senescence and eryptosis, evidenced primarily by much faster clearance of eryptotic cells compared to senescent erythrocytes [78]

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Bioavailability is usually determined by calculating the respective plasma drug exposure assessed as the total area under the drug plasma concentration versus time curve (AUC) after oral and intravenous administration as: In general, determinants of oral drug bioavailability include fraction of dose absorbed in the gastrointestinal tract (GIT) and fraction of dose that escapes elimination by the intestinal tract, liver, and lung