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The transcription factor (TF) Srebf1 (SREBP-1c) plays a central role in lipogenesis, and it is activated by insulin, glucose, or fatty acids, with its expression level maintained by itself as an autoregulatory feed-forward loop during lipogenesis (25, 26)

A full review of the microbiota and its interactions with intestinal barrier function is outside the scope of this article and the interested reader is directed to several recent reviews [812]