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The specific mechanisms by which elevated homocysteine contributes to cardiovascular pathologies and whether interventions to lower homocysteine levels are beneficial remain areas of debate and investigation

Early pharmacology work described it as a selective growth-hormone secretagogue, with GH release and little ACTH or cortisol signal in the foundational studies

& DeLoughery, T

1193-1201 [online] Available at: (accessed 7th April 2022) Ars, C.L., Nijs, I.M., Marroun, H.E., Muetzel, R., Schmidt, M., Steenweg-de Graaff, J., Van der Lugt, A., Jaddoe, V.W., Hofman, A., Steegers, E.A., Verhulst, F.C., Tiemeier, H

Drmic et al., 2017, 2018