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On the road: extracellular vesicles in intercellular communication

as intranuclear Nrf2 is decreased in AD, this causes the accumulation of ROS, senescent organelles, and misfolded proteins [174]

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Additionally, deprivation of Cl - facilitates Ca 2+ influx by promoting the release of PGE2 [91]

The enzyme sterol 14-demethylase (CYP51), which is involved in ergosterol biosynthesis, has been successfully targeted by azole compounds, such as posaconazole and ketoconazole ( Leishmania proliferation and differentiation, making them attractive targets for kinase inhibitors (Naula et al., 2005)