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For High Oxidative Stress or Detox Support Individuals dealing with heavy pollution exposure, smoking history, chronic stress, or metabolic imbalance may require higher support, typically 1,0002,000 mg per day (NIH)

48, 49 However, claudin-2 also serves other diverse functions including paracellular passage of cations (including sodium and calcium), cell proliferation and autophagy, and loss of claudin-2 along with claudin-15, yet another TJ protein implicated in paracellular Na + passage, results in premature death because of malnourishment in mice

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