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endotoxin) can trigger systemic inflammation that further exacerbates neuroinflammation, illustrating how brain disorders are not confined to the CNS but involve a systemic network including the gut ecosystem [16]

Additionally, issues such as the oxidation of BH 4 to inactive forms like BH 2 limit its therapeutic potential ( 4 is also a cofactor of phenylalanine hydroxylase, which converts phenylalanine to tyrosine, a precursor to catecholamines

To this effect, several studies have shown that antioxidant supplementation of the culture media may improve pregnancy outcomes