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A common regimen includes estradiol treatment, with small initial doses and gradual progression, and the development of secondary sex characteristics can be observed ( Table 1 Some medications to protect ovarian function

blood will be analysed for haemoglobin concentration immediately after collection at enrolment by using HemoCue

All data were analyzed using the SAS software package, release 9.4 (SAS Institute), or using R software (R version 4.1.2)