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In organisms undergoing catabolism, the E3 ligases Atrogin-1 (also called MAFbx or FBXO32) and MuRF-1 (also called Trim63) are specifically expressed

Le Trong I, Stenkamp RE, Ibarra C, Atkins WM, Adman ET

Soni, N

However, it is important to note that clinical translation of these approaches does face several challenges: profound metabolic and molecular heterogeneity between patients (and even within tumors), difficulties in achieving adequate drug penetration across the blood-brain barrier, and the risk of toxicity in normal cerebral tissue

A Double-Blind Randomized Trial of Hyperbaric Oxygen for Persistent Symptoms after Brain Injury