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Think of the reconstituted vial as a highly sensitive reagent

The epithelium of the non-inflamed ileum shows a normal permeability to ions and a normal paracellular permeability to 51 Cr-EDTA as compared to controls (119, 120) but is more susceptible to a challenge with sodium caprate indicating that TJs in the non-inflamed ileum of CD are more reactive to luminal stimuli contributing to the development of mucosal inflammation (120)

What the Research Shows In the STEP 1 clinical trial, published in Diabetes, Obesity and Metabolism (Wiley), participants receiving semaglutide 2.4 mg once weekly achieved an average weight loss of 17.3% over 68 weeks, compared with 2.0% in the placebo group

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