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( d ) BrdU incorporation (left) and % relative survival (right) in cells transduced with shRNA targeting IDH1 (n = 3 technical replicates representative from 3 independent experiments in each cell line)

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In addition to structural regulation at the mitochondrial level, cells utilize CMA as a selective mechanism for mitochondrial protein clearance

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Reactive oxygen species via redox signaling to PI3K/AKT pathway contribute to the malignant growth of 4-hydroxy estradiol-transformed mammary epithelial cells