Clinical trials with drugs that are already actively used in the clinic have several advantages, because drug repurposing can undergo a fast track regarding regulations [265]
Handling and Stability Risks Improper handling exposure to light, heat, repeated freeze-thaw cycles, or strongly alkaline conditions can degrade the peptide or disrupt copper coordination, producing experimental variability that is sometimes mistaken for biological inconsistency
doi: 10.2332/allergolint.R-07-159 71 FitzgeraldDCCiricBTouilTHarleHGrammatikopolouJDas SarmaJet al
Clockaerts S, Van Osch GJ, Bastiaansen-Jenniskens YM, Verhaar JA, Van Glabbeek F, Van Meurs JB, Kerkhof HJ, Hofman A, Stricker BH, Bierma-Zeinstra SM
FDA-approved peptide drugs Understanding FDA-approved peptides helps appreciate the broader research landscape