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Although the specific genes and pathways may vary, differential DNA methylation in pediatric under- and overnutrition affect genes regulating similar metabolic processes and result in similar disease outcomes

Secondary outcome measurements included reduction in body weight from baseline by at least 5% or 10% by week 26, changes in waist circumference, total cholesterol, HDL, LDL, VLDL, and triglycerides, and levels of different glycemic variables including HbA1C, fasting plasma glucose, fasting insulin, insulin resistance, and the functioning of beta-cells

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