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Observed effects are dependent on experimental design, concentration, and model system, and are used for mechanistic exploration rather than defined biological outcomes

Free radicals are formed as a result of intense effort, stress, or environmental pollution, and their excess accelerates aging processes

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In this review, we summarise the complex metabolic pathway of Vitamin B12, the inherited and acquired causes of Vitamin B12 deficiency and subsequently highlight the disparate international practice of prescribing Vitamin B12 replacement therapy

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