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Scientists have uncovered specific genes that affect melanin production and longevity, making hereditary factors the most consistent predictor of when hair transitions from its natural color to the first gray hair

Tazawa K, Shimojima Y, Okano T, Yazaki M, Takei Y, Shimojo H, Kobayashi K, Saheki T, Ikeda S

Cancer Prev Res 5(2):179188 Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S, Petrie K, Iyer NG, Prez-Rosado A, Calvo E et al (2005) Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

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Titration should rely on objective measures, including semen analysis for concentration and progressive motility, and serial hormone panels that include LH, FSH, and testosterone