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When selenium is reduced, some selenoproteins in the body quickly disappear (low grades), while others can continue to be synthesized even when selenium levels are reduced (high grades) ( GPX2 was the first selenoprotein identified as a target of the Wnt pathway, and its promoter contains five -catenin/TCF binding sites (TBE) (Figure 2)

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10.1016/j.molmet.2021.101428 47 ZhangY.SwandaR