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The expanded approval was based on data from the Phase III EoE KIDS trial, where 66% of children who received the higher dose Dupixent at tiered dosing regimens experienced histological disease remission after 16 weeks of treatment, compared to just 3% in the placebo group, per the press release
Anyone with copper-metabolism disorders, active malignancy, or during pregnancy/breastfeeding should avoid it, and everyone should consult a licensed clinician first
The mechanism of DPP-4 inhibitors is to increase incretin levels (GLP-1 and GIP), [2] [3] [4] which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels
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Its important to note that results may vary, and this therapy is not a guaranteed solution for every individual
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