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Inhibition of both NOS and peroxynitrite formation has generally been reported to antagonize opioid tolerance, especially but not exclusively when NOS is inhibited after the induction of opioid tolerance (Tayfun Uzbay and Oglesby, 2001

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These findings are in agreement with the clinical observation of a positive correlation between serum Zn and adiponectin levels in obese patients with polycystic ovary syndrome [86]

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