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It is reported that in traditional tobacco, stimulating human pulmonary artery smooth muscle cells (PASMCs) and endothelial cells (PAECs) leads to COX-2 production, which in turn drives cell proliferation [38]

Wellman RJ, Dugas EN, Dutczak H, OLoughlin EK, Datta GD, Lauzon B et al (2016) Predictors of the onset of cigarette smoking: a systematic review of longitudinal population-based studies in youth

This understanding allowed the two to become close friends and collaborate on some of the most treasured images in the Dylan oeuvre, including this one of the enigmatic genius in a sullen state, a cigarette resting in his mouth

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Is that reductionist approach