(Outlines contraindications for niacin therapy, including active peptic ulcer disease, active liver disease with elevated enzymes, hypersensitivity to niacin, and arterial bleeding, as well as monitoring recommendations for blood pressure, glucose, uric acid, etc., due to niacins systemic effects)
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Rushing this process, skipping dose levels, or starting at a higher dose to accelerate weight loss dramatically increases side effect severity
This provides a theoretical basis for the development of anticancer drugs targeting GLUD1 [40]