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In hyperuricemia management, synthetic gene networks integrating HucR-based biosensors and secreted Aspergillus flavus urate oxidase achieve self-regulated urate degradation, dynamically adjusting enzyme expression to maintain physiological UA levels while avoiding excessive urate depletion ( 2 O 2 neutralization, with enhanced renal targeting and catalytic durability (Tables 1 and 2

doi:10.1016/j.nut.2020.110941 233

1-3 These episodes can be excruciating and last for days