Its version without Drug Affinity Complex (DAC) typically has a shorter half-life measured in hours, while the DAC-modified version can remain active for several days because the modification slows degradation since the DAC component allows the peptide to bind to albumin in the bloodstream, extending circulation time
In a model of traumatic brain injury in rats, allicin attenuated brain edema, neurological deficits, and apoptotic neuronal death, and exhibited antioxidant and anti-inflammatory effects, partly by increasing Akt-mediated eNOS activation (31)
Acknowledgments This work was conducted at the University of Colorado Denver Health Sciences Center (UCDHSC)
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