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GPxs exert their antioxidant effect mainly by using glutathione (GSH) as a reductant to accelerate the reaction of H 2 O 2 into water via catalysis [26]

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Water concentrations were calculated based on the volume fractions of white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF), assuming their water concentrations as 35,880 mM, 43,300 mM, and 55,556 mM, respectively [52]