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This can cause methyl trapping, where the excess methylfolate is unable to be utilised in the methionine cycle (through the MTR enzyme) as usable B12 levels are too low

A Critical Review on the Health Benefits of Fish Consumption and its Bioactive Constituents

Toxicology 156(1):3745

Patients with mild, recently developed deficiency typically respond more rapidly than those who have been deficient for months or years