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Institutions including Mayo Clinic and Cleveland Clinic have been direct about this

Through interactions with PGC-1 coactivators and chromatin regulators, ERRs govern programs for mitochondrial biogenesis, oxidative phosphorylation (OXPHOS), lipid catabolism, and angiogenesis

doi: 10.1186/s40168-017-0332-0 63 Stavreus EversA

202 Additional meta-analyses have also concluded that probiotics, prebiotics, and synbiotics can reduce oxidative stress, decrease inflammation, improve lipid levels, and heighten glucose metabolism in CKD patients