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Several direct targets of valproate have been discovered including the mitochondrial enzymes, succinate semialdehyde dehydrogenase and long-chain fatty acid-CoA ligase-4, as well as the family of nuclear-localised histone deacetylases that are involved in epigenetic regulation of gene expression [179,180,181]

Several pathways related to carbohydrate metabolism were also represented in the top 25 pathways, such as Galactose metabolism, Starch and sucrose metabolism, and Pyruvate metabolism (Fig

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