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Weight loss during this stage is often modest

A study found that D5R, via the EFD and IYX(X)I/L motifs in its CT and IC3 loop, respectively, can directly recruit TRAF6 and its negative regulator ARRB2, as well as downstream signaling proteins, such as TAK1, IKKs, and PP2A, to form a multiprotein complex, which impairs TRAF6-mediated activation of NF-B (91)

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For an additional insight into the mechanism of action, the tumorous tissue was stained with a ROS-specific dye and analyzed by CLSM

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