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It forms a complex with TFE3 and TRIM28 that enhances H3K4me3, an activating mark, at the promoters of ATG5, LC3B , and GABARAPL1 , thus leading to their transcriptional upregulation

The logics of this approach, where FRET is enhanced due to the translational diffusion as a donor-acceptor pair that is too far apart for efficient transfer at the instant of excitation may diffuse toward each other during the excited-state lifetime so that the distance between them becomes short enough for efficient transfer (Elkana et al., 1968

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Fricker M, Qin L, Sanchez-Ovando S, Simpson JL, Baines KJ, Riveros C, Scott HA, Wood LG, Wark PA, Kermani NZ, et al