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On the experiment day, 100 mM IBMX (3-isobutyl-1-methylxanthine) was prepared by dissolving 22.2 mg in 100% DMSO and diluted in DMEM D1145 to a final concentration of 500 M

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In a phase 2 dose-finding trial, once-weekly Cagrilintide produced clinically meaningful weight loss about 10.8% at the 4.5 mg dose over 26 weeks with gastrointestinal effects the most common adverse events [1]

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