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In the case of individuals intending to conceive, the use of metformin may be continued until pregnancy is confirmed, whereas for those not actively pursuing pregnancy, metformin may be administered until normalization of glucose regulation is achieved

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Expanded Clinical Pathways Category 1 status would provide clearer regulatory footing and could enable structured, compliant prescribing pathways

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10.1038/s41598-018-31144-8 61 SenP.FanY.SchlezingerJ