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Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: An update

A typical four-week titration schedule for cognitive research models follows this pattern: Week 1 : 0.5mg/kg three times weekly (Monday/Wednesday/Friday) Week 2 : 1.0mg/kg three times weekly Week 3 : 1.5mg/kg three times weekly Week 4 : 2.0mg/kg three times weekly The three-day dosing interval (every 4872 hours) accounts for Dihexa's estimated half-life of 24 hours in rodent models, allowing complete clearance between doses while maintaining cumulative exposure over the study period

Executive Summary 1.1

Sim TM, Ong SJ, Mak A, Tay SH

Gong MJ, et al