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The fungal ubiquitous enzyme, alcohol dehydrogenase (EC 1.1.1.1), plays an essential role in metabolism and growth [40]

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Beyond fungal infections, TBK1 is also implicated in tumor immune evasion by reducing the sensitivity of tumor cells to TNF- and IFN-, thereby dampening anti-tumor immunity (Sun et al., 2023a)

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While the body has systems in place to repair damaged cells, persistent oxidative stress overwhelms those mechanisms, setting off a chain reaction of cellular dysfunction