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Results first, gas chromatography/mass spectrometry (GC/MS)-based untargeted metabolomics revealed that bTNF- altered the metabolism of bFLS, increasing glucose, isoleucine, leucine, methionine, valine, tyrosine, and lysine and decreasing malate, fumarate, -ketoglutarate, stearate, palmitate, laurate, aspartate, and alanine