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Rapamycin, administered in combination with inhibitors of HSP90, causes mitochondrial damage with accompanying oxidative stress and autophagy and reduces tumor growth in RAS -dependent tumors 120

Some enzymes require certain nutrient cofactors, so nutrient deficiencies can interfere with production

Cell Stress Chaperones 24 , 283287 (2019)

These patients, who collectively account for 25-30 percent of all people with major depression disorder, are precisely the ones most in need of effective pharmacological interventions, said Rasgon, who performed the bulk of the advanced data analysis for the study

PMID: 30746212