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Aldred PMR, Hollox EJ, Armour JAL: Copy number polymorphism and expression level variation of the human -defensin genes DEFA1 and DEFA3

That these relationships were seen in hepatocytes, myocytes, and brown adipocytes, but were conspicuously absent in fibroblasts, hints that oxidative metabolism might represent an intrinsic challenge to ER functionality and might explain why feeding itself appears to be an ER stressor

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doi: 10.1016/j.tins.2008.06.006 54

It's crucial to adhere to pharmaceutical guidelines and product inserts for safe administration