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The methodological quality of the included studies, as assessed through the Jadad and NewcastleOttawa scales, varied from moderate to high, while the GRADE assessment indicated moderate certainty of evidence for serum vitamin B12 increase and low certainty for homocysteine reduction

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While these renal markers returned to baseline after a recovery period (washout), the data suggests that Adipotide research requires careful monitoring of renal function markers (BUN and creatinine) and hydration status

Side effects like reactions at the injection site are common