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Symptoms of B12 deficiency include exhaustion no matter how much you sleep, muscle weakness and frequent cramping, constipation, loss of appetite and unexplained weight loss, numbness or tingling in the hands and feet, depression, and problems with memory and focus

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Thus, cell survival is largely dependent on sustained physiological levels of NO [22]

superoxide anion (O2), singlet oxygen radical (1O2), peroxyl radical (ROO), nitric oxide radical (NO) and lipid peroxy radical (LOO) as well as peroxynitrate (ONOO), trichloromethane (CHCl3) and hypochlorous acid (HOCl) which are not necessarily free radicals but have high tendency to generate free radicals

However, it is important to consult a healthcare provider for proper diagnosis and treatment of nerve pain