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Adverse events that may occur with methotrexate include rash, nausea, mucositis, diarrhea, bone marrow suppression, infections, pneumonitis, increased liver enzyme levels, and liver fibrosis or cirrhosis
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Clinical studies have measured improvements in skin firmness of 20-30% after 12 weeks of topical GHK-Cu treatment
This multi-modal strategy costs less than repeated professional-only treatments producing superior long-term outcomes versus topical-only protocols potentially producing incomplete results in moderate to severe cases