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Excessive ROS-induced autophagy can also lead to cell death (96)

Metabolic complications of obesity in children and adolescents

Although various candidate interventions and antioxidants have demonstrated protective effects against ROS production and lipid peroxidation in diabetic hearts, further clinical trials are necessary to establish the definitive connection between ferroptosis and diabetic cardiomyopathy

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Furthermore, it has been proposed that these routes activate cell survival pathways to prevent death, although in extreme oxidative stress apoptosis is favored even above necrosis