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Blocking the Notch pathway or the NF-B pathway tended to counteract the pro-angiogenic implications of TB-500 in both cell lines and murine models

Thrombus formation and the subsequent activation of the coagulation cascade with final generation of fibrin is facilitated by the mCRP-mediated enhancement of tissue factor on the endothelial cell surface, platelet aggregation and thrombus growth (207, 208) (Figure 7)

Gray bars indicate GSH/GSSG-Glo Assay only whereas green bars indicate GSH/GSSG-Glo Assay multiplexed with the CellTox Green Cytotoxicity Assay

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