Functional assays validate metabolic activity at Day 30, demonstrating comparable performance to widely used models such as primary human hepatocytes (PHHs) and HepaRG cells
In some of such embodiments, the immediate release formulations described herein are substantially free of extended release components
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In order to collect a sufficient number of cells for implantation, isolated chondrocytes usually undergo an extensive expansion from 0.10.2 million to 4060 million cultured chondrocytes gradually lose the proliferative capacity and the potential of generating the cartilage-specific matrix, a phenomenon known as dedifferentiation
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