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It is used to treat Vitamin B12 deficiency, pernicious anemia, and certain nerve-related conditions

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and (2) mitochondrial dysfunction, leading to neuroinflammation, impaired neuroprotection, and age-related disease progression (Jiang and Cadenas, 2014

140 It is important to note that not all CFE systems are suitable for a given target protein, particularly for small peptides, 442 and thus it may be important to evaluate multiple different CFE systems for the production of the desired molecule

A "Strong" rating indicates support from multiple well-designed trials, "Moderate" suggests promising but less consistent findings, and "Limited" or "Emerging" applies to areas with early-stage, small, or mixed research